Application of morpholine in medicine

Morpholine, also known as morpholine and 1,4-Oxazinane  has a very wide range of industrial uses and can be used as an intermediate for many fine chemicals. We can find morpholine in many fields such as rubber, medicine, pesticides, coatings, textiles, and medical equipment. In the pharmaceutical field, morpholine and its derivatives are mainly used in the production of analgesics, sedatives, local anesthetics, respiratory and vasodilator stimulants, body strengthening drugs, antispasmodics and antimalarial drugs, such as morpholine, cloth and other common drugs on the market. Profen, naproxen, sodium phenylacetate, dichloroaniline, etc.

Among the morpholine drugs, muscarinic acetylcholine receptor (mAChRs) antagonists, also known as M receptor antagonists, are used as anti-peptic ulcer drugs. In the process of acid secretion by gastric parietal cells, M receptors, histamine H2 receptors and gastrin receptors are involved and play a promoting role. In addition, M receptors are also involved in processes such as movement control, body temperature regulation, cardiovascular regulation, and memory in the central nervous system. In the peripheral nervous system, they are involved in smooth muscle contraction, gland secretion, and regulation of heart rate and myocardial contractility. Therefore, indications for M-receptor antagonists also include smooth muscle spasm, anesthesia, nausea and vomiting, and motion sickness.